When you first identify the fire ant you should kill it by slapping it off your body and consequently washing the sting site with soap and cold water. In regards to the itching, it can last for hours and an oral antihistamine can be taken or a topical steroid ointment applied such as hydrocortisone. This same treatment is effective for a local reaction and a large local reaction. The hydrocortisone ointment can be covered with first aid tape to increase absorption of the steroid. Very large local reactions are treated with a prescription steroid ointment and/or an oral corticosteroid such as prednisone. If the patient develops anaphylaxis they should be treated emergently and also evaluated by an allergist. The allergist can administer desensitizing injections in the event the patient is stung again by a fire ant.