Stimulants microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumetsinol, rifampin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increases the production of hydroxylated active metabolites, which leads to the possibility of severe intoxication, even with a small overdose. Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of taken together with salicylates nephrotoxicity of paracetamol increases. Combination with chloramphenicol, increases the toxic properties of the latter. Enhances deca steroids the effect of indirect anticoagulants, reduces the effectiveness of uricosuric drugs.
All anabolic steroids have a tendency to reduce HDL (good) cholesterol and increase LDL (bad) cholesterol. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable) type of steroid (aromatizable or non-aromatizable) and level of resistance to hepatic metabolism. With regards to nandrolone at a dose of 600mg per week over 10 weeks demonstrated 26% reduction in HDL cholesterol levels. This suppression is slightly greater than an equal dose of testosterone over an equal period. In other words it shows a slightly more negative impact on HDL/LDL ratio with nandrolone than with testosterone cypionate. It’s always recommended to accompany the use of this product with a low saturated fat diet and a cardiovascular exercise program.