Non steroid topical cream

Dermal embryofetal developmental studies were conducted in rabbits and rats with Hydrocortisone Valerate Cream, %. Hydrocortisone Valerate Cream, %, was administered topically for 4 hours/day, rather than the preferred 24 hours/day, during the period of organogenesis in rats (gestational days 5-16) and rabbits (gestational days 6-19). Topical doses of hydrocortisone valerate up to 9 mg/kg/day (54 mg/m 2 /day) were administered to rats and 5 mg/kg/day (60 mg/m 2 /day) were administered to rabbits. In the absence of maternal toxicity, a significant increase in delayed skeletal ossification in fetuses was noted at 9 mg/kg/day [ the Maximum Recommended Human Dose (MRHD) based on body surface area (BSA) comparisons] in the rat study. No malformations in the fetuses were noted at 9 mg/kg/day ( MRHD based on BSA comparisons) in the rat study. Indicators of embryofetal toxicity, significant decrease in fetal weight at 2 mg/kg/day (1X MRHD based on BSA) and a significant increase in post-implantation loss and embryo resorption at 5 mg/kg (3X MRHD based on BSA), were noted in the rabbit study. A significant increase in delayed skeletal ossification in fetuses was noted at 5 mg/kg/day (3X the MRHD based on BSA comparisons) in the rabbit study. Increased numbers of fetal malformations (., cleft palate, omphalocele and clubbed feet) were noted at 5 mg/kg/day (3X MRHD based on BSA comparisons) in the rabbit study.

You can buy some topical corticosteroids "over-the-counter" without a prescription. For example, for dermatitis, you can buy the steroid cream called hydrocortisone 1% from your pharmacy. Do not apply this to your face unless your doctor has told you to do so. This is because it may trigger a skin condition affecting the face ( acne or rosacea. ) Long-term use may also damage the skin. On your face this would be more noticeable than the rest of your body. So usually only weak steroids are used on the face. Those which are suitable are prescription-only.

Like other topical corticosteroids, hydrocortisone valerate has anti-inflammatory, antipruritic and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins , collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A 2 .

For the past 17 months I have participated in the no steroid creme re TSW. Wow, it has been a journey, but I do believe you are correct with all you information. I am still NOT where I would like to be,but probably 60 percent better than with steroid cremes. I live in Switzerland and have have done uva and uvb light therapy as well, and visited Avene thermal spa. I also spent a fair amount of time on the Atlantic ocean trying to heal. So, as I see you have commented on Eucrisa tm.. (criaborole). I would like to comment, that I experienced a severe reaction to the creme after 8 days of use… ( the company Pfizer has my photos etc )

The most common side effect of topical corticosteroid use is skin atrophy. All topical steroids can induce atrophy, but higher potency steroids, occlusion, thinner skin, and older patient age increase the risk. The face, the backs of the hands, and intertriginous areas are particularly susceptible. Resolution often occurs after discontinuing use of these agents, but it may take months. Concurrent use of topical tretinoin (Retin-A) % may reduce the incidence of atrophy from chronic steroid applications. 30 Other side effects from topical steroids include permanent dermal atrophy, telangiectasia, and striae.

Non steroid topical cream

non steroid topical cream

For the past 17 months I have participated in the no steroid creme re TSW. Wow, it has been a journey, but I do believe you are correct with all you information. I am still NOT where I would like to be,but probably 60 percent better than with steroid cremes. I live in Switzerland and have have done uva and uvb light therapy as well, and visited Avene thermal spa. I also spent a fair amount of time on the Atlantic ocean trying to heal. So, as I see you have commented on Eucrisa tm.. (criaborole). I would like to comment, that I experienced a severe reaction to the creme after 8 days of use… ( the company Pfizer has my photos etc )

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