According to the American Academy of Pediatricians : The single most effective active ingredient in any diaper rash treatment is zinc oxide. Pinxav starts with 30% zinc oxide; compare Pinxav to any other brand as far as their active ingredient! Then we add our unique, proprietary combination of ingredients to augment the effectiveness, and heal and soothe your Babies’ gentle skin. Most all diaper rash treatments are effective in creating a barrier against further wetness and irritation, that is the main property of zinc oxide. We add natural ingredients that work to stop the pain, and actually start healing the skin. Diaper rash is painful, and can be destructive left untreated – we work to treat all of the symptoms. We want your Baby as happy as you do!