Damage incurred by traumatic brain injury is believed to be caused in part by mass depolarization leading to excitotoxicity . One way in which progesterone helps to alleviate some of this excitotoxicity is by blocking the voltage-dependent calcium channels that trigger neurotransmitter release.  It does so by manipulating the signaling pathways of transcription factors involved in this release. Another method for reducing the excitotoxicity is by up-regulating the GABA A , a widespread inhibitory neurotransmitter receptor. 
If a steroid cream is purchased over the counter, the package should disclose the steroid used, and the strength, such as one percent hydrocortisone cream. Generally, the cream should not be used for more than a week, unless a doctor has specifically recommended an over the counter product for extended use. If the condition does not respond or grows worse, the over the counter cream should be discontinued, and an appointment should be made with a dermatologist , who can examine the site and prescribe a different medication or course of treatment.
It is also suggested that there is an interaction between hormone levels and eating at different points in the female menstrual cycle . Research has predicted increased emotional eating during hormonal flux, which is characterized by high progesterone and estradiol levels that occur during the mid- luteal phase . It is hypothesized that these changes occur due to brain changes across the menstrual cycle that are likely a genomic effect of hormones. These effects produce menstrual cycle changes, which result in hormone release leading to behavioral changes, notably binge and emotional eating. These occur especially prominently among women who are genetically vulnerable to binge eating phenotypes.