Steroids change gene expression

$EXEL
http:///press-release/bristolmyers/bristol-myers-squibb-announces-top-line-results-checkmate-026-phase-3-stu
Thoughts:
1) BMY will look at EXEL more closely for combinations due to their 1L failure in lung cancer using Opdivo. RCC, and Lung are two top markets for IO drugs and Exelixis presumably works in both. There was a mention of potential in lung cancer combination trial during the earnings call.
2) Japan deal could be made now that earnings are out, they might be asking for more money due to Cabosun now being pursued for FDA approval for 1L RCC albeit confidentially.
3) After Japanese deal, and Ipsen European payment Exelixis might have a larger sum of money to pay down the convertible debt in cash and stock combination.
4) Potential bidding war for Exelixis between BMY, Pfizer, and Roche.

Help I have a friend who is a gym goer Im not sure of his quantity or how long he has been taking steroids, but stopped recently because he had really bad neck pain. No dr or scan, ultrasound etc showed anything. Put on huge pain killer amounts didnt help alot but felt after about six weeks some relief. Until today when he thinks a prior knee issue has flared up. If this a result of steroid abuse how long before it heals? Im pretty sure he wont touch them again. He can handle all over aches and pains but these last two injuries have had him off work.

Great question! Calcified gallstones are typically the last stones to come out from the gallstone flush. Reason being – they are much heavier than the typical cholesterol stones, where gravity causes them to sink to the lower part of your gallbladder. These stones can be quite stubborn to remove, but it varies from person to person. Some people pass them on their first flush, while it may take up to 6 to 9 flushes for others. Because they are heavier, they will not float in water like cholesterol stones, but will sink. That is a good way to tell if you’ve passed any.

Remember, nothing is alleged to--or can have--happened to all of MLB over some one or two seasons: the claim is that PEDs were being used at a slowly but steadily increasing rate (and thus "distorting records") from very roughly 1980 through the present. Were that so, or anything like it, we would expect to see a clear long-term uptrend during this period. But we don't: we see a nearly flat line that, if anything, slopes slightly down. The "boost" just isn't there. But that doesn't seem to stop anyone from talking about it.

Steroids change gene expression

steroids change gene expression

Remember, nothing is alleged to--or can have--happened to all of MLB over some one or two seasons: the claim is that PEDs were being used at a slowly but steadily increasing rate (and thus "distorting records") from very roughly 1980 through the present. Were that so, or anything like it, we would expect to see a clear long-term uptrend during this period. But we don't: we see a nearly flat line that, if anything, slopes slightly down. The "boost" just isn't there. But that doesn't seem to stop anyone from talking about it.

Media:

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