The combined use of sertraline and substances which depress the central nervous system requires attention, and also prohibited the use of alcoholic beverages during treatment with sertraline. The derivatives of coumarin – when coadministered with sertraline showed a significant increase in prothrombin time – in these cases it is recommended to monitor the prothrombin time at the beginning of treatment with sertraline and after its cancellation. Sertraline is associated with plasma proteins. It is therefore necessary to consider the possibility of interaction with other drugs that bind to the protein (eg, diazepam, tolbutamide and warfarin). Cimetidine: simultaneous use significantly reduces the clearance of sertraline. Drugs metabolized isoenzyme : long-term treatment with sertraline 50 mg per day accompanied by increased concentrations of de zipramina.
Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. 
Negative cardiovascular risks , side effects, and cholesterol changes are a known side effect shared by all anabolic steroids, and this side effect does apply to Turinabol side effects. Negative cardiovascular side effects resultant from anabolic steroid use involves the reduction of HDL (the good cholesterol) and increases of LDL (the bad cholesterol ). The result of such changes involves an increased risk of arteriosclerosis, and the degree to which these changes occur for the worse are usually dose-dependent (with higher doses increasing the negative changes and the risks). Other factors that affect these negative cholesterol changes are: duration of use, and route of administration. In terms of the route of administration, oral anabolic steroids are known for having a reputation as being much worse for their negative impacts on cholesterol in comparison to injectable anabolic steroids. This is because the liver serves to function as the cholesterol processing center for the human body, and the increased hepatotoxicity associated with anabolic steroids will result in even worse negative cholesterol changes.